Intake of nanoparticles and impact on gut microbiota: <i>in vitro</i> and animal models available for testing

نویسندگان

چکیده

ABSTRACT The oral delivery of compounds associated with diet or medication have an impact on the gut microbiota balance, which in turn, influences physiologic process. Several reports shown significant advances clarifying impact, interactions and outcomes intake nanoparticles human gut. These may affect bioavailability delivered compounds. In addition, there is a considerable breakthrough development antimicrobial for intestinal pathogenic bacteria. vitro fermentation vivo models been developed throughout years were used to test these systems. methodologies studies carried out so far modulation animal microbiome by nanosized materials reviewed. Overall, available mimic real physiological events enabling select best production conditions nanoparticulate systems preliminary stage research. On other hand, can be access dosage effect, safety correlation between haematological, biochemical symptoms, groups metabolites.

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ژورنال

عنوان ژورنال: Gut microbiome

سال: 2021

ISSN: ['2632-2897']

DOI: https://doi.org/10.1017/gmb.2021.5